Eksplorasi Potensi Sediaan Gel Antiinflamasi Ekstrak Bawang Dayak (Eleutherine Palmifolia) terhadap Penyembuhan Luka Sayat pada Kelinci New Zealand White (Oryctolagus Cuniculus)
DOI:
https://doi.org/10.71417/galen.v3i1.321Keywords:
Bawang Dayak, Eleutherine palmifolia, gel antiinflamasi, penyembuhan luka, luka sayat, New Zealand WhiteAbstract
Latar Belakang: Luka sayat memerlukan penanganan yang tepat untuk mempercepat proses penyembuhan, terutama pada fase inflamasi yang berperan dalam menentukan keberlanjutan regenerasi jaringan. Bawang Dayak (Eleutherine palmifolia) mengandung metabolit sekunder yang berpotensi memberikan aktivitas antiinflamasi dan mendukung penyembuhan luka. Tujuan: Penelitian ini bertujuan mengeksplorasi potensi sediaan gel ekstrak Bawang Dayak terhadap penyembuhan luka sayat serta menentukan konsentrasi yang paling efektif pada kelinci New Zealand White (Oryctolagus cuniculus). Metode: Penelitian eksperimental menggunakan tiga ekor kelinci jantan New Zealand White dengan enam perlakuan, yaitu kontrol normal, kontrol positif Bioplacenton®, kontrol negatif basis gel, serta gel ekstrak Bawang Dayak konsentrasi 5% (F1), 10% (F2), dan 15% (F3). Pengamatan dilakukan selama 14 hari terhadap karakteristik fisik sediaan, iritasi, hiperemia, edema, eksudat, re-epitelisasi, panjang luka, dan persentase penyembuhan luka. Data dianalisis menggunakan One-Way ANOVA dan uji LSD. Hasil: Seluruh formula gel menunjukkan karakteristik fisik yang baik dan tidak menimbulkan iritasi. Formula F3 (15%) menunjukkan aktivitas penyembuhan paling cepat di antara formula ekstrak, dengan persentase penyembuhan mencapai 100% pada hari ke-7 dan panjang luka mencapai 0 cm pada hari ke-9. Penutupan luka sempurna pada F2, F1, F0, kontrol positif, dan kontrol negatif masing-masing terjadi pada hari ke-10, 11, 13, 8, dan 12. Analisis One-Way ANOVA menunjukkan adanya perbedaan signifikan antarkelompok perlakuan (F = 26,066; p = 0,000). Kesimpulan: Sediaan gel ekstrak Bawang Dayak konsentrasi 15% merupakan formula paling efektif dalam mempercepat penyembuhan luka sayat dibandingkan formula gel ekstrak lainnya dan menunjukkan potensi untuk dikembangkan sebagai sediaan topikal pendukung penyembuhan luka.
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