Dissociative Convulsions Mimicking Epileptic Seizures: A Diagnostic Challenge in a Patient with Complex Psychosocial Stressors
DOI:
https://doi.org/10.71417/galen.v2i2.229Kata Kunci:
Dissociative Convulsions, Functional Seizures, Psychogenic Non Epileptic Seizures, Psychosocial Stressors, Seizure MimicryAbstrak
Dissociative convulsions are paroxysmal events resembling epileptic seizures yet occurring without ictal epileptiform activity, and they are frequently misdiagnosed or delayed, especially in resource‑limited settings. This study aims to describe the diagnostic process, clinical course, and psychosocial context of dissociative convulsions in a 29‑year‑old woman with complex psychosocial stressors, and to illustrate a structured management approach. The research adopted a qualitative case study design, employing a descriptive‑analytic paradigm and inductive analysis. Data were collected from a single case meeting the criteria for dissociative convulsions (F44.5), evaluated in a psychiatric outpatient setting, through comprehensive clinical interviews, mental status examination, behavioral observations, and documentation of semiotic seizure features, alongside routine EEG, CT head, and laboratory tests. Data were analyzed thematically by identifying patterns of semiotics, psychosocial triggers, and treatment response. The result shows that seizure‑like episodes emerged in close temporal relation to interpersonal conflict and reproductive losses, were accompanied by prominent autonomic symptoms, and occurred against a background of adverse childhood experiences and borderline‑type personality traits. The conclusion highlights that a careful semiotic assessment, normal ancillary investigations, and thorough psychosocial evaluation support the diagnosis of dissociative convulsions, even without video‑EEG monitoring, and that a multimodal biopsychosocial strategy combining psychoeducation, cognitive‑behavioral therapy, grounding techniques, and pharmacotherapy effectively reduces seizure frequency and psychosocial impairment.
Unduhan
Referensi
Abi-Nahed, R., Li, J., Carlier, J., Birca, V., Bérubé, A.-A. and Nguyen, D.K. (2024) ‘Outcome of psychogenic non-epileptic seizures following diagnosis in the epilepsy monitoring unit’, Frontiers in Neurology, 15, p. 1363459. doi:10.3389/fneur.2024.1363459.
Anis, S., Fahoum, F., Korczyn, A.D., Goldberg-Stern, H., Gilboa, T., Kipervasser, S., Neufeld, M.Y. and Medvedovsky, M. (2022) ‘Using semiology to classify epileptic seizures vs psychogenic nonepileptic seizures: a meta-analysis’, Neurology: Clinical Practice, 12(3), pp. 234–242. doi:10.1212/CPJ.0000000000001170.
Asadi-Pooya, A.A. (2017) ‘Psychogenic nonepileptic seizures: a concise review’, Neurological Sciences, 38(6), pp. 935–940. doi:10.1007/s10072-017-2887-8.
Aybek, S. and Perez, D.L. (2022) ‘Diagnosis and management of functional neurological disorder’, BMJ, 376, p. o64. doi:10.1136/bmj.o64.
Brown, R.J. and Reuber, M. (2016) ‘Towards an integrative theory of psychogenic non-epileptic seizures (PNES)’, Clinical Psychology Review, 47, pp. 55–70. doi:10.1016/j.cpr.2016.06.003.
Carozzino, D., Sciarra, A., Olivola, M., Bortolato, M., Brondino, N. and Politi, P. (2025) ‘Preliminary findings from a mindfulness-based intervention in patients with psychogenic non-epileptic seizures’, Brain Sciences, 15(10), p. 1037. doi:10.3390/brainsci15101037.
Creswell, J. W. (2021). Research design: Qualitative, quantitative, and mixed methods approaches (6th ed.). SAGE Publications.
Diprose, W., Sundram, F. and Menkes, D.B. (2016) ‘Psychiatric comorbidity in psychogenic nonepileptic seizures compared with epilepsy’, Epilepsy and Behavior, 56, pp. 123–130. doi:10.1016/j.yebeh.2015.12.037.
Gargiulo, Á.J.M., Colombini, A.P., Trovato, A., Gargiulo, A.P.I. and D’Alessio, L. (2022) ‘Functional/dissociative seizures: review of its relationship with trauma, dissociation and the neurobiological underpinnings’, Neuroscience Applied, 1, p. 100109. doi:10.1016/j.nsa.2022.100109.
Emzir. (2022). Metodologi penelitian kualitatif: Analisis data. Jakarta: Rajawali Pers.
Gasparini, S., Beghi, E., Ferlazzo, E., Beghi, M., Belcastro, V., Biermann, K.P., Bottini, G., Capovilla, G., Cervellione, R.A., Cianci, V., Coppola, G., Cornaggia, C.M., De Fazio, P., De Masi, S., De Sarro, G., Elia, M., Erba, G., Fusco, L. and Aguglia, U. (2024) ‘Personality disorders in individuals with functional seizures: a systematic review’, Frontiers in Psychiatry, 15, p. 1411189. doi:10.3389/fpsyt.2024.1411189.
Gargiulo, A. J. M., Colombini, A. P., Trovato, A., Gargiulo, A. P. I., & D’Alessio, L. (2022). Functional/dissociative seizures: Review of its relationship with trauma, dissociation and the neurobiological underpinnings. Neuroscience Applied, 1, 100109. https://doi.org/10.1016/j.nsa.2022.100109
Gilmour, G.S., MacIsaac, R., Subotic, A., Wiebe, S. and Josephson, C.B. (2021) ‘Diagnostic accuracy of clinical signs and symptoms for psychogenic nonepileptic attacks versus epileptic seizures: a systematic review and meta-analysis’, Epilepsy and Behavior, 121(Pt A), p. 108030. doi:10.1016/j.yebeh.2021.108030.
Goldstein, L.H., Robinson, E.J., Mellers, J.D.C., Stone, J., Carson, A., Reuber, M., Medford, N., McCrone, P., Murray, J., Richardson, M.P., Pilecka, I., Eastwood, C., Moore, M., Mosweu, I., Perdue, I., Landau, S. and Chalder, T. (2020) ‘Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial’, The Lancet Psychiatry, 7(6), pp. 491–505. doi:10.1016/S2215-0366(20)30128-0.
Goldstein, L.H., Robinson, E.J., Reuber, M., Chalder, T., Callaghan, H., Eastwood, C., Landau, S., McCrone, P., Medford, N., Mellers, J.D.C., Moore, M., Mosweu, I., Murray, J., Perdue, I., Pilecka, I., Richardson, M.P., Stone, J. and Carson, A. (2019) ‘Characteristics of 698 patients with dissociative seizures: a UK multicenter study’, Epilepsia, 60(11), pp. 2182–2193. doi:10.1111/epi.16350.
Hingray, C., Ertan, D., Reuber, M., Lother, A.S., Chrusciel, J., Tarrada, A., Schwan, R., Sanchez, S., El-Hage, W. and Maillard, L. (2022) ‘Heterogeneity of patients with functional/dissociative seizures: three multidimensional profiles’, Epilepsia, 63(7), pp. 1500–1515. doi:10.1111/epi.17230.
Jeyagurunathan, A., Abdin, E., Shah, M.I.M.K., Lee, Y.T., Sagayadevan, V.D., Shafie, S., Sambasivam, R., Yunjue, Z., Xinyi, K., Eng, L.M.F., Ting, T.C.C., Basu, S., Chandwani, N., Lee, S.Y.L., Liu, J., Chong, S.A. and Subramaniam, M. (2025) ‘Prevalence and clinical correlates of intimate partner violence (IPV) among women with mental illness’, European Psychiatry, 68(S1), p. S427. doi:10.1192/j.eurpsy.2025.427.
Kanemoto, K., LaFrance, W.C. Jr, Duncan, R., Gigineishvili, D., Park, S.-P., Tadokoro, Y., Ikeda, H., Paul, R., Zhou, D., Taniguchi, G., Kerr, M., Oshima, T., Jin, K. and Reuber, M. (2017) ‘PNES around the world: where we are now and how we can close the diagnosis and treatment gaps – an ILAE PNES Task Force report’, Epilepsia Open, 2(3), pp. 307–316. doi:10.1002/epi4.12060.
Kerr, W.T., Janio, E.A., Le, J.M., Hori, J.M., Patel, A.B., Gallardo, N.L., Bauirjan, J., Chau, A.M., D’Ambrosio, S.R., Cho, A.Y., Engel, J. Jr, Cohen, M.S. and Stern, J.M. (2017) ‘Diagnostic delay in psychogenic seizures and the association with anti-seizure medication trials’, Seizure, 40, pp. 123–126. doi:10.1016/j.seizure.2016.06.009.
Lucena, K.D.T. de, Vianna, R.P. de T., Nascimento, J.A. do, Campos, H.F. de C. and Oliveira, E.C.T. de (2017) ‘Association between intimate partner violence and the incidence of common mental disorders’, Revista de Saúde Pública, 51, p. 32. doi:10.1590/S1518-8787.2017051006311.
Ludwig, L., Pasman, J.A., Nicholson, T., Aybek, S., David, A.S., Tuck, S., Kanaan, R.A., Roelofs, K., Carson, A. and Stone, J. (2018) ‘Stressful life events and maltreatment in conversion (functional neurological) disorder: systematic review and meta-analysis of case-control studies’, The Lancet Psychiatry, 5(4), pp. 307–320. doi:10.1016/S2215-0366(18)30051-8.
Peeling, J.L. and Muzio, M.R. (2024) ‘Psychogenic nonepileptic seizures’, in StatPearls. Treasure Island, FL: StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK441871/ (Accessed: 12 May 2026).
Pick, S., Goldstein, L.H., Perez, D.L. and Nicholson, T.R. (2019) ‘Emotional processing in functional neurological disorder: a review, biopsychosocial model and research agenda’, Journal of Neurology, Neurosurgery and Psychiatry, 90(6), pp. 704–711. doi:10.1136/jnnp-2018-319201.
Popkirov, S., Asadi-Pooya, A.A., Duncan, R., Gigineishvili, D., Hingray, C., Miguel Kanner, A., LaFrance, W.C. Jr, Pretorius, C. and Reuber, M. (2019) ‘The aetiology of psychogenic non-epileptic seizures: risk factors and comorbidities’, Epileptic Disorders, 21(6), pp. 529–547. doi:10.1684/epd.2019.1107.
Sharma, S., Dixit, V., Arya, A., Agarwal, V. and Gupta, P.K. (2022) ‘Brief online psychotherapy for psychogenic non-epileptic seizures using the psychoeducation-motivational interviewing-self appraisal-grounding (PMSG) model: a multiple baseline case series study’, Asian Journal of Psychiatry, 77, p. 103269. doi:10.1016/j.ajp.2022.103269.
Sudaryono. (2023). Metodologi penelitian klinis psikiatrik di Indonesia: Pendekatan kualitatif dan kuantitatif. Yogyakarta: Penerbit Pustaka Ilmu.
Sugiyono. (2022). Metode penelitian kuantitatif, kualitatif, dan R&D. Bandung: Alfabeta.
Tabib, F., Guermazi, F., Masmoudi, R., Mnif, D., Feki, I., Baati, I. and Masmoudi, J. (2024) ‘Prevalence and patterns of post-traumatic stress disorder in victims of intimate partner violence’, European Psychiatry, 67(S1), p. S639. doi:10.1192/j.eurpsy.2024.1382.
Tolchin, B., Baslet, G., Suzuki, J., Martino, S., Blumenfeld, H., Hirsch, L.J., Altalib, H. and Dworetzky, B.A. (2019) ‘Motivational interviewing techniques to improve psychotherapy adherence and outcomes for patients with psychogenic nonepileptic seizures’, Journal of Neuropsychiatry and Clinical Neurosciences, 32(2), pp. 125–131. doi:10.1176/appi.neuropsych.19020045.
Villagran, A., Eldoen, G., Duncan, R., Aaberg, K.M., Hofoss, D. and Lossius, M.I. (2021) ‘Incidence and prevalence of psychogenic nonepileptic seizures in a Norwegian county: a 10-year population-based study’, Epilepsia, 62(7), pp. 1528–1535. doi:10.1111/epi.16949.
Voon, V., Cavanna, A.E., Coburn, K., Sampson, S., Reeve, A. and LaFrance, W.C. Jr (2016) ‘Functional neuroanatomy and neurophysiology of functional neurological disorders (conversion disorder)’, Journal of Neuropsychiatry and Clinical Neurosciences, 28(3), pp. 168–190. doi:10.1176/appi.neuropsych.14090217.
White, S.J., Sin, J., Sweeney, A., Salisbury, T., Wahlich, C., Montesinos Guevara, C.M., Gillard, S., Brett, E., Allwright, L., Iqbal, N., Khan, A., Perot, C., Marks, J. and Mantovani, N. (2024) ‘Global prevalence and mental health outcomes of intimate partner violence among women: a systematic review and meta-analysis’, Trauma, Violence, & Abuse, 25(1), pp. 494–511. doi:10.1177/1524838023115552
Diterbitkan
Terbitan
Bagian
Lisensi
Hak Cipta (c) 2026 Ardita Da’imah Cahyani, Era Catur Prasetya (Author)

Artikel ini berlisensiCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.












