Pharmacokinetic Prediction Of Apigenin From Celer (Apium Graveolens L.) Using Pkcsm
DOI:
https://doi.org/10.71417/galen.v1i1.3Kata Kunci:
Apium Graveolens, Apigenin, Pharmacokinetics, ADMET, PKCSMAbstrak
Celery (Apium graveolensL.) is a plant that has various pharmacological activities. One of the main bioactive compounds in celery is apigenin. Understanding the pharmacokinetic properties of apigenin is very important in evaluating its effectiveness and safety as a drug candidate. This study aims to predict the pharmacokinetic properties of apigenin using the pkCSM computational approach. The prediction results show that apigenin has good intestinal absorption, but low water solubility. Distribution ability is moderate, with limited penetration into the central nervous system. Apigenin is not a major substrate of CYP2D6 and CYP3A4 enzymes, but can inhibit CYP1A2 and CYP3A4. The elimination rate is moderate. Apigenin is not mutagenic, not hepatotoxic, and does not cause cardiotoxic effects. Apigenin has low toxicity toT. pyriformisand safe in acute doses with an LD50 of 2,432 log mM.
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Referensi
Abdullah, SS, Putra, PP, Antasionast, I., Rundengan, G., Suoth, EJ, Abdullah, RP, & Abdullah, F. (2021). Analysis of Physicochemical, Pharmacokinetic and Toxicological Properties of Pericarpium of Nutmeg (Myristica Fragransa) Using Artificial Intelligence.Chemistry Progress, 81-92. doi:https://doi.org/10.35799/cp.14.2.202 1.37112
Al-Asmari, AK, Athar, MT, & Kadasah, S.G. (2017). An Updated Phytopharmacological Review on Medicinal Plant of Arab Region: Apium graveolens Linn.Pharmacogn. Rev. doi:10.4103/phrev.phrev_35_16
DeRango-Adem, E., & Blay, J. (2021). Does Oral Apigenin Has Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?Frontiers in Pharmacology. doi:https://doi.org/10.3389/fphar.2021.6 81477
Garrido, A., Lepailleur, A., M. Mignani, S., Dallemagne, P., & Rochais, C. (2020). hERG toxicity assessment: Useful guidelines for drug design.European Journal Of Medicinal Chemistry, 195. doi:https://doi.org/10.1016/j.ejmech.202 0.112290
Latif, MS, Rusdiana, T., & Gozali, D. (2017).Review Article: Effect of P Glycoprotein (P-Gp) on Atorvastatin Bioavailability.Pharmacy, 15. doi:https://doi.org/10.24198/jf.v15i3.15 418.g7427
Muslikh, FA, Dhafin, AA, & Prasetyawan, F. (2023). Prediction of Pinostrobin Pharmacokinetics from Key Gathering. Contemporary Journal of Applied Sciences (CJAS), 1-6. doi:https://doi.org/10.55927/cjas.v1i1.69 77
Pharmacokinetic Properties. (2025, 2 22). Retrieved from pkCSM : https:// biosig.lab.uq.edu.au/pkcsm/ prediction_single/adme_1740192915.03
Pires, D.E., Blundell, T., & B. Ascher, D. (2015). pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures.Journal of Medicinal Chemistry. doi:https://doi.org/10.1021/acs.jmedche m.5b00104
PubChem. (2025). Retrieved from https://pubchem.ncbi.nlm.nih.gov/comp ound/5280443
Rusdiana, T. (2018). Celery Plant Study (Apium Graveolens L.) As a Source of High Potential Natural Ingredients in Health Promotion Efforts.Indonesian Natural Research Pharmaceutical Journal. doi:https://doi.org/10.52447/inspj.v3i1.8 74
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Hak Cipta (c) 2025 Lusiana Aprillia , Fendy Prasetyawan , Yuneka Saristiana , Ratna Mildawati , Chandra Arifin, Abd Rofiq (Author)
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